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Declaration of Helinski

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Tutorials and Fundamentals
placebo

The Placebo Effect

Do placebos really promote physiological change or is it just the patient’s perspective? How are placebos used in practice? And how ethical is it to use placebos in clinical trials?

Tutorials and Fundamentals
emergency care

Experimenting in an emergency: are clinical trials always justified?

Conducting trials where the trialled therapeutic must be commenced urgently raises specific practical and ethical problems. Here I discuss a recent New England Journal of Medicine paper looking at the use of intracranial pressure monitoring for severe traumatic brain injury as an example of how these issues may affect a trial’s utility and how this can be managed.

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