Is this study valid? Can I trust this study’s methods and design? Can I apply the results of this study to other contexts? Learn more about internal and external validity in research to help you answer these questions when you next look at a paper.
Conducting trials where the trialled therapeutic must be commenced urgently raises specific practical and ethical problems. Here I discuss a recent New England Journal of Medicine paper looking at the use of intracranial pressure monitoring for severe traumatic brain injury as an example of how these issues may affect a trial’s utility and how this can be managed.
This slideshow shows how the data generated in trials and analysed in systematic reviews can be applied in clinical practice.
An essay discussing the underpinnings of EBM and the difficulties of using it in clinical practice
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